【摘 要】
：
代谢综合症是一种多种代谢成分异常聚集的病理状态，包括：(1)腹部肥胖或超重，(2)动脉粥样硬化血脂异常(3)高血压(4)胰岛素抗性及/或，其中慢性肾病是代谢综合症的严重并发症之一。很多的患者由于肾病的进展失去了肾功能，导致过早死亡或进入肾透析状态。大量的数据证明肾素-醛固酮-血管紧张素系统在糖尿病肾病病理机理中起了非常重要的作用，包括纤维化调节因子刺激、氧自由基增加、肾小球内压的增高、肾小管间质缺
【机 构】
：
首都医科大学附属北京同仁医院 中国
【出 处】
：
2013第三届内分泌与代谢大会暨2013第二届糖尿病大会
论文部分内容阅读
代谢综合症是一种多种代谢成分异常聚集的病理状态，包括：(1)腹部肥胖或超重，(2)动脉粥样硬化血脂异常(3)高血压(4)胰岛素抗性及/或，其中慢性肾病是代谢综合症的严重并发症之一。很多的患者由于肾病的进展失去了肾功能，导致过早死亡或进入肾透析状态。大量的数据证明肾素-醛固酮-血管紧张素系统在糖尿病肾病病理机理中起了非常重要的作用，包括纤维化调节因子刺激、氧自由基增加、肾小球内压的增高、肾小管间质缺氧的诱导。 总而言之，肾素-醛固酮-血管紧张素系统主要调节肾内纤维化因子和超氧化物。
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