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Objective: To assess the effects of pharmaceutical care interventions on blood pressure (BP) and medication adherence of patients with primary hypertension in China.Methods: A total of 60 patients with primary hypertension were enrolled in the trial for a 12-month period.Participants were randomized to either control group or intervention group in a 1∶1 ratio.During the follow-up period, patients in control group were given regular medi-care, while patients in intervention group accepted pharmaceutical care.The dates of baseline demographics, medication lists, measurement of medication adherence, BP values were collected.Statistical analyses were conducted using t test or x2 test.Results: After 12 months follow-up, 24-hour BP was significantly decreased 9.75 mmHg (7.1%) for systolic blood pressure (SBP) and 5.88 mmHg (6.6%) for diastolic blood pressure (DBP) in the intervention group (p<0.05) compared with their initial visit, while there is no significant change in the control group (p>0.05).The intervention group demonstrated a higher percentage of patients with high adherence (72.41%) at 12 months, whereas control group hardly had changes in medication compliance.Conclusion: Our results indicate that pharmaceutical care intervention might contribute to better BP control of primary hypertension, and could enhance medication compliance of patients.