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While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models,recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases.It is less clear if iTregs can treat the established autoimmune diseases.We now provide evidence that unlike nTregs,injection ofiTreg cells can markedly ameliorate the established autoimmune asthma,arthritis and lupus.