Objective To explore the relationship between renal function within normal range of serum creatinine and characteristics of coronary artery disease (CAD) and investigate the association between renal function and cardiovascular prognosis.Method A total of 548 hospitalized and angiographic CAD patients within normal range of serum creatinine were enrolled.All patients serum creatinine were measured after fasting.The kidney function was estimated by using the abbreviated Modification of Diet in Renal Disease (MDRD) study equation.All patients were divided into three tertile groups according to eGFRtertile.There were 182 cases in high eGFR group (108.47±20.09) mL·min-1·1.73m-2, 184 cases in intermediate group (79.18±5.14) mL·min-1·1.73m-2, 177 cases in low eGFR group (61.03±7.12) mL·min-1·1.73m-2.All patients clinical data and established cardiovascular risk factors were recorded after admission and all patients were tracked for 14.02 ± 8.31 months.The primary end point was combination occurrence of major adverse cardiovascular and cerebral events (MACCE), including death, targeted vascular revascularization, non-fatal myocardial infarction, rehospitalization due to unstable angina and heart failure, and transient ischemic attack (TIA) and stroke.Results Patients who were within normal range of serum creatinine with intermediate and loweGFR level were older, more males, had more severity of coronary artery, higher level of hsCRP, higher rates of hypertension, and lower rates of smoking patients than those with high eGFR level.All of above had reached statistically significant (P<0.05).A total of 89 MACCE occurred during following up.The level ofeGFR was obviously lower in the patients with MACCE than that in the patients without MACCE [(73.76±19.81)mL·min-1·1.73m-2 vs (84.97±23.42) mL·min-1·1.73m-2, P<0.05].In univariate and multivariate Cox regression analysis eGFR is an independent predictors of MACCE in patients with CAD (univariate analysis: RR=0.99, 95% CI: 0.973-0.997, P=0.015) and (multivariate analysis: RR=0.98, 95% CI: 0.976-0.998, P=0.027).Kaplan-Meier survival analysis suggested that patients with low eGFRhad a decreased event free survival ratio (log-rank x2=7.271, P=0.026).Conclusions eGFR level within normal range ofserumcreatinine is associated with coronary artery severity, inflammation level and independently predicts the prognosis of coronary artery disease.