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Objective:The aim is to screen out risk factors affecting bone mass states transition for postmenopausal osteoporosis(PMOP)based on western medicine risk factors and traditional Chinese medicine(TCM)symptoms.Methods:The questionnaire survey and bone mineral density tests were conducted lasting for 3 years from March 2009 to November 2011.Every subject was regularly contacted and interviewed annually.The characteristics of the population with different bone mass states transition were described.Risk factors were selected through univariate and multivariate analysis of Markov model.Likelihood ratio test was used to compare the fitting effect of different variables for the same data.Results:A total of 1021 participants were followed up for three consecutive years.In the period of follow up,80 women suffered the normal-osteopenia transition,43 women suffered the osteopenia-osteoporosis transition.Duration of menopause,height loss,and TCM symptoms including soreness and weakness of waist and knees,hair loss and leg pains were possible western medicine risk factors of transition states for PMOP(P<0.05).Fresh vegetables diet could reduce the risk of transition(P<0.05).The Markov model based on the western medicine risk factors and TCM symptoms had a satisfactory fitting degree.Conclusion:The importance of TCM symptoms should be paid attention to the screening and early warning of the population with high risk of PMOP.Markov model could be used for identifying risk factors of bone mass states transition for PMOP.