目的:研究microRNA-181a对高脂饮食诱导的apoE-/-小鼠肾损伤的保护作用.方法:将apoE-/-小鼠分为4组:Normal diet组,HFD组、HFD+NC-m组、HFD+181a-m组.5周ApoE-/-小鼠高脂饮食或正常饮食12周后,NC-m组尾静脉注射negative control mimics,181a-m组尾静脉注射miR-181a-mimics(50μg/kg/w),
[Objectives]To establish the rat model of secondary osteoporosis in rheumatoid arthritis (RA) and investigate the characteristics of RA to induce osteoporosis in the course of disease development.At t