【摘 要】
:
Objective: Multiple myeloma is a plasma cell malignancy which generally develops destructive osteolytic bone disease.The thiored oxindomain containing five (TXNDC5) is a protein-disulfide isomerase of
【机 构】
:
State Key Laboratory of Medical Molecular Biology,School of Basic Medicine,Peking Union Medical Coll
【出 处】
:
第八届全国医学生物化学与分子生物学、第五届全国临床应用生物化学与分子生物学、2013华东六省一市生物化学与分子生物学联合
论文部分内容阅读
Objective: Multiple myeloma is a plasma cell malignancy which generally develops destructive osteolytic bone disease.The thiored oxindomain containing five (TXNDC5) is a protein-disulfide isomerase of thioredoxin family.Our study aimed at understanding the role of TXNDC5 in multiple myeloma.
其他文献
Background and Aim The Methylene Tetrahydrofolate Reductase (MTHFR) C677/T polymorphism and investigation of blood lipid correlative indexes which includes homocysteine (HCY), lipoprotein (a) (Lp (a))
目的:RYBP(Ring1 and YY1 binding protein)是一个潜在的抑癌基因,其mRNA水平在肝癌组织和部分肝癌细胞系中的表达降低.由于RYBP围绕第一个外显子区的CpG含量较高,因此,本研究利用分子生物学的方法从几株肝癌细胞出发,探索RYBP表达降低与其启动子区甲基化水平的关系.
目的 观察生存素(SURVIVIN)基因干扰对SW480细胞增殖的影响,探讨其干扰对hTERT基因表达的影响及机制.方法 构建携带Survivin小发夹干扰RNA的重组表达载体pGenesil-1.1-Survivin,转染结肠癌SW480细胞,MTT检测细胞增殖改变,流式细胞仪检测细胞增殖周期的改变;荧光定量PCR和Western-blot检测Survivin、hTERT和Sp1的mRNA和蛋白
Background The phenotypes of vascular smooth muscle cells (VSMCs) can switch between differentiated and dedifferentiated states, which are essential for repair of vascular injury.
目的 在整体基因水平上探索调肝方药经前舒颗粒和经前平颗粒对郁怒和愤怒大鼠海马基因表达谱影响,以明确其可能药物作用靶点、信号调控网络和作用机理。
目的 探讨ApoE敲除小鼠模型外周Th 17/Treg平衡变化及全反式维甲酸对平衡的影响.方法 8周龄ApoE(-/-)小鼠分为高脂组(给予高脂饮食)和ATRA治疗组(高脂饮食同时予以ATRA灌胃),同时设8周龄C57 BL/6J小鼠对照组(给予普通饲料).
Our previous study have revealed that the glucose-responsive transcriptional factor carbohydrate responsive element binding protein (ChREBP) plays a key role in regulating aerobic glycolysis,anabolism
With the rapid development of electric power and wireless communication technologies over the last several decades, public concerns have been raised about possible health effects (e.g.brain cancer ris
Recently, a novel class of transcripts, long noncoding RNAs (lncRNAs), is being identified at a rapid pace.These RNAs act critical roles in diverse biological processes including tumorigenesis.
目的 探讨全反式维甲酸(All-Trans Retinoic Acid, ATRA)及其衍生物(ATRP)对RKO细胞增殖、迁移和侵袭的影响及其相关机制.方法:培养RKO细胞,MTT法检测ATRA及ATRP对RK细胞增殖能力的影响同时确定用药浓度.流式细胞术、细胞划痕试验分别检测ATRA及ATRP对RKO细胞增殖、迁移和侵袭能力的影响.