论文部分内容阅读
For therapy and regeneration of bone defects resulting from malignant bone disease,it is of great importance to develop multifunctional biomaterials for bone therapy and regeneration.Conventional biomaterials always lack multifunctional properties,limiting their application for treating and repairing bone disease(e.g.bone tumors)-initiated defects.How to design and prepare bioscaffolds with favorable microenvironments for disease therapy and tissue regeneration is one of interesting topics in the fields of biomaterials and tissue engineering.We developed several strategies,including harnessing nutrient elements,biomimetic structure and functional interface as well as thermo-therapy to construct multifunctional scaffolds by 3D-Pringting method for therapy and regeneration of bone tissues.It is interesting to find that both nutrient elements and biomimetic structure of the printed bioscaffolds have important effect on the stimulation of osteogenesis and angiogenesis of stem cells,and thermotherapy plays an important role to treat bone tumors.Therefore,we put forward new concept that 3D-Printed bioscaffolds combined bone therapy and regeneration could be a new direction of bone tissue engineering.