姜黄素衍生物C086诱导K562细胞凋亡与线粒体途径的关系

来源 :2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 | 被引量 : 0次 | 上传用户：mkkkj2009

【摘要】

：

目的姜黄素(curcumin,Cur)具有抗肿瘤、抗炎、抗血小板聚集等广泛的药理作用及毒性小等特点,是一种较有潜力的抗癌先导化合物.课题组前期工作发现姜黄素对多种肿瘤细胞有明显的体外杀伤作用,显示了良好的抗肿瘤活性,但是姜黄素水溶性差、生物利用度低的缺点限制了它的使用.鉴于此,本课题组合成了C086[4-(4-羟基-3-甲氧基苯亚甲基)姜黄素],其生物利用度优于姜黄素.本研究旨在探讨了C086诱

【作者】

：

陈瑞家吴丽贤刘洋陈开杰周义湘许建华

【机构】

：

福建医科大学药学院药理系;福建医科大学新药研究所;福建天然药物药理学重点实验室福建医科大学药学院

【出处】

：

2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议

【发表日期】

：

2013年12期

【关键词】

：

姜黄素凋亡线粒体半胱氨酸蛋白酶

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姜黄素衍生物C086诱导K562细胞凋亡与线粒体途径的关系

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