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Local anaesthetics, procaine (Pro), lidocaine (Lid), ropivacaine (Rop) and bupivacaine (Bup), are often used intravenously, epidurally, topically or subcutaneously to relieve pain during and after medical procedures.But, local anesthetics are potentially toxic if they are administered in high doses or into the wrong anatomic site, reaching the major target organs of toxicity, the brain and heart.Sensitive determination of the local anesthetics is necessary for biochemical and clinical analysis.