【摘 要】
：
Selenium (Se) is an essential dietary component for animals including humans, and there is increasing evidence for the efficacy of certain forms of selenium
【机 构】
：
US Department of Agriculture Agricultural Research Service Grand Forks Human Nutrition Research Cent
【出 处】
：
BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
Selenium (Se) is an essential dietary component for animals including humans, and there is increasing evidence for the efficacy of certain forms of selenium as cancer-chemopreventive compounds.In addition, Se appears to have a protective effect at various stages of carcinogenesis including both the early and later stages of cancer progression.Mechanisms for Se-anticancer action are not fully understood, however, several have been proposed: antioxidant protection, enhanced carcinogen detoxification, enhanced immune surveillance, modulation of cell proliferation (cell cycle and apoptosis), inhibition of tumor ce11 invasion, and inhibition of angiogenesis.Cell-cycle analysis revealed that Se deficiency caused a decrease in G1 Phase cells that corresponded to an increase in G2 and sub-G1 phase cells.
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