Cryptosporidium parvum is the most important common enteropathogen inhabiting in many animals.Infections of C.parvum in immunocompetent livestock are commonly asymptomatic or self-limited,but it can be life-threaten in immunocomprised or immunodeficent hosts.Unfortunately,there have been no efficient treatment and prevention measures to control cryptosporidiosis currently and better understanding of the immune response to this parasite is required.