CD27/CD27L蛋白在胰腺癌组织中的表达及临床意义

来源 :中华医学会第十七届全国外科学学术会议 | 被引量 : 0次 | 上传用户:fbcpingqi
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目的 观察CD27和CD27L蛋白在胰腺癌和正常胰腺组织中的含量,探讨其与肿瘤发生、增殖、转移及临床病理特征和临床分期的关系.方法 采用ELISA法和Western blot试验对39例胰腺癌组织和35例正常胰腺组织中CD27和CD27L蛋白的含量进行检测.结果 与正常胰腺组织相比,胰腺癌组织中CD27蛋白含量未出现明显变化(P>0.05),但CD27L蛋白含量显著升高(P<0.001).Spearman秩相关分析表明CD27和CD27L之间无显著相关性(P>0.05).CD27L蛋白在肿瘤组织中的表达含量与患者年龄、性别、肿瘤位置无相关性(P</span>>0.05),与肿瘤直径、病理类型、淋巴结转移、神经侵犯、TNM分期密切相关(P</span><0.05),并且随着病理类型的增高而增高(P</span><0.05).
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