Involvement of Epithelial Stem/Progenitor Cells in Gastric Carcinogenesis

来源 :BIT Life Sciences' 1st Annual World Cancer Congess-2008( | 被引量 : 0次 | 上传用户:s8583527
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  Gastric cancer is the second leading cause of cancer deaths worldwide.It occurs commonly in the pyloric antrum which is normally lined by two main mucous cell types: pit and gland mucous cells.These cells originate from epithelial progenitor cells which are responsible for the renewal of the whole epithelium.It is not known whether these stem/progenitor cells are involved in the development of gastric cancer.The aim of this study was to follow the changes that occur in epithelial stem/progenitor cells during the early stages of gastric carcinogenesis in trefoil factor 1-knockout mice which with age develop spontaneous adenomas and carcinomas in the pyloric antrum.Two lectins, UEA-1 and GSII, were used as markers for pit and gland mucous cells, respectively.
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