论文部分内容阅读
Somatic cell reprogramming is accompanied by changes in lipid metabolism.While attempting to dissect the molecular mechanisms of the lipid metabolic switch during reprogramming,we found that overexpression of sterol regulatory element binding protein-1(Srebp-1),a transcriptional factor required for lipid homeostasis,enhances reprogramming efficiency,while knockdown or pharmaceutical inhibition of Srebp-1 is inhibitory.