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Objective:To investigate the effects of Xuebijing injection on blood coagulation function and blood gas analysis in severe sepsis patients.Methods:64 patients of severe sepsis were randomly divided into two groups:control group (32cases) and treatment group (32cases).The basic treatments of two groups included primary disease treatment,anti-infection,adrenal cortical hormone treatment and keeping the balance of water-electrolyte.The treatment group was supemumerarily injected with Xuebijing injection 100mL and 5% glucose solution injection 250mL for 7d,bid.prothrombin time(PT),activated partial thromboplastin time(APTT), fibrin(Fib), thromboplastin time(TT), parameter of blood platelets and blood gas analysis were measured before the treatment and 7days after the treatment.PT,APTT, Fib,TT, parameter of blood platelets and blood gas analysis of two groups were compared before and after the treatment.Results: Compared with those before the treatment,PT, APTT, TT increased, Fib increased, parameter of blood platelets improved and the oxygenation were improved in both groups after the treatment(P < 0.01).Compared with control group,PT,APTT and TT increased,Fib increased, parameter of blood platelets improved and the oxygenation were improved in treatment group.However,the mortality between two groups had no significant difference (P > 0.05).Conclusion :Xuebjing parenteral solution could improve blood coagulation function and oxygenation in severe sepsis patients.So,it could be a new approach for clinical treatment of severe sepsis.