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novel biomimetic drug delivery system(BDDS)inspired by the pH-dependent ferric ion-transport and release manner of transferrin(Tf)was developed for combating multidrug-resistant breast cancer.Tf-inspired carrier was synthesized by modifying bovine serum albumin(BSA)with histamine(HA)through amide reaction to provide superior specific coordination sites for ferric ion-drug complexes,and self-assembled into nanoparticles(NPs)induced by coordination bond.