Parkinsons disease (PD) is a neurodegenerative disorder of unknown etiology primarily resulting from the death of dopaminergic neurons in the substantia nigra.The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular events that provoke neurodegeneration.The observation that the degree of terminal loss in the striatum appears to be more pronounced than the magnitude of SNpc dopaminergic neuron loss,suggests that striatal dopaminergic nerve terminals are the primary target of the degenerative process and that neuronal death in PD may result from a "dying back" process,which makes us to hypothesize that microtubule in striata might be a target for the initiation of the disastrous process occurring in dopaminergic neurons in PD.