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Compared to hyaluonan(HA) with high molecular weight,HA with low molecular weight (LMWHA) has different or diverse biological activities.The biological activities of HA are closely related to its molecular weight.Up to now,the molecular weight range of LMWHA has not been defined,but generally HA with average molecular weight of 1×104 to 50×104 is considered as LMWHA.