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Background: Haemophilus influenzae, Streptococcus pneumoniae, and Streptococcus pyogenes are the most common causative bacterial pathogens of Community-acquired respiratory tract infections (CARTI), and an increase in their resistance to orally administered β-lactam agents has emerged as a global problem.Tebipenem and cefditoren are two novel oral antibiotics which exhibit a wide range of antibacterial activity.This study is to determine the in vitro activities of the two novel oral antibiotics and other comparators against CARTI-associated bacterial pathogens.Methods: A total of 275 isolates of S.pneumoniae, H.influenzae and S.pyogenes were isolated from 10 hospitals in six cities of China.The minimum inhibitory concentrations (MICs) of 16 antimicrobial agents were determined by using broth microdilution method.The H.influenzae isolates were examined for the production of β-1actamase using nitrocefin disks.