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Objective Previously, we demonstrated the importance ofT-cell immune response cDNA 7 (TIRC7) in acute i mmune thrombocytopenia (ITP).As the downstream molecule of TIRC7, cytotoxic T lymphocyte antigen-4 (CTLA-4) has been verified its negative regulation of acute ITP.This study aimed to investigate the exact role of CTLA-4 and its relationship with TIRC7 in acute ITP.