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Objective To explore the functional role of aberrant expression and modification of transcription factors in the pathogenesis of thymic carcinoids causing ectopic ACTH syndrome (EAS).Methods Expression level of transcription factors was determined by RT-PCR,which was further confirmed by Western blot.Overexpression and siRNA knockdown of the transcription factor was performed in murine pituitary tumor cell line AtT-20 to analyze its functional role in glucocorticoid (Gc) mediated pro-opiomelanocortin (POMC) feedback.