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Objective To explore the clinical trial of the digital acupoint pressure on the imbalances of Jin-Gu of knee osteoarthritis (KOA) base on the theory of uneven settlement.Methods Totally 160 cases of the grade 1 and 2 stage KOA (221 knees) were randomized into treatment group (80 cases, 111 knees) and the control group (80 cases, 110 knees).Both groups were given glucosamine hydrochloride capsules, while the diclofenac emulsion and digital acupoint pressure was added in the control group and the treatment group with a course of four weeks, respectively.The therapeutic effect was evaluated by comparing the scores of knee movement function and the Western Ontario and McMaster Universities (WOMAC) OA Index before and after treatment.