Diabetes mellitus is a potent metabolic disorder of this time.Due to the progression of disease itself and along with the collateral damages by its various complications this is being considered as one of the greatest threat to patients well being & status.During recent years the prevalence of ulceration in diabetic patients especially foot ulcer has dramatically increased, causing tremendous negative impact over the patient.But unfortunately, there is no reliable animal model that resembles human diabetic foot ulcer, thus the study of ulcer healing under conditions of "diabetes mellitus" remains a challenge.