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Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer.The approach of these patients should be multidisciplinary.Historically, radiation Oncology played a key role in the management of the disease, both in use after chemotherapy and mastectomy, as in non-surgical treatment associated with chemotherapy.Several fractionation shemes of radiotherapy have been described in medical literature.In this presentation, we present an extensive and critical review of these treatments involving radiotherapy and the experience with long-term followup of nonsurgieal treatment of these patients.It is important to place the important role of radiotherapy for this patients at the time of the avaibility of many suitable targeted agents.