Inhibition of the vascular endothelial growth factor receptor(VEGFR) has emerged as one of the most promising new method for cancer therapy.Based on the computer technology,one compound with the pyrazole core has been found by the silico screen,which has presented moderate inhibitory activity against the proliferation of human umbilical vein endothelial cells(HUVEC).With the compound as the lead compound,some compounds with the pyrazole nucleus have been designed,synthesized and valuated by MTT.Some of them present satisfactory activity.