Wnt signaling pathway plays an essential role in tumor invasion and migration.DKK1 is an important inhibitor of Wnt signaling pathway and is a promising target for cancer therapy.The present study was
近年来,在国际妇科医师的协作努力下,卵巢癌的化学治疗取得了一定的进展.基于现有的循证医学证据,早期卵巢癌无高危因素者无需术后辅助化疗,晚期卵巢癌标准治疗仍为肿瘤细胞减灭术及术后铂类为基础的联合化疗;腹腔化疗可延长满意的肿瘤细胞减灭术后患者生存时间,但难于普及推广应用,尚不能取代传统静脉化疗;新辅助化疗可减少围手术期并发症的发生,提高手术成功率,但不能改善长期生存;巩固化疗可延长患者PFS,但OS亦
Objects Radical hysterectomy (RH) has a negative impact on cancer survivorsquality of life as a result of a shortened vagina, vaginal dryness and dyspareunia.The article aims to explore the effect of
目的 研究miR-135a对卵巢上皮性癌细胞系SKOV3细胞中HOXA10基因表达及细胞增殖和凋亡的影响.方法 (1)应用生物信息学技术预测与miR-135a高度相关的靶基因.(2)将miR-135a mimics、miR-135a inhibitor及阴性对照分别转染SKOV3细胞,采用RT-PCR技术和蛋白印迹法检测转染不同时间后SKOV3细胞中HOXA10 mRNA和蛋白的表达水平.(3)报
Background Recruitment and angiogenic roles of endothelial progenitor cells (EPCs) are subjected to regulation by the vascular microenvironment, which remains largely unknown.Cyr61 is a secreted matri
Background Hydrogen sulfide (H2S) is found to be the third endogenous gaseous transmitter and plays an important role in many systems of organism.In cardiovascular system, H2S is produced endogenously
Background Bone marrow (BM) derived hematopoietic stem cells (HSCs) show potential to differentiate and regenerate myocardium after ischemic injury.Stem cell mobilization, egress from BM, and homing t
Background Phenotypic modulation of adventitial fibroblasts (AFs) plays an important role in the pathogenesis of proliferative vascular diseases.The current study aimed to identify the role of cellula
Background Atherosclerosis is an inflammatory disease characterized by the formation of atherosclerotic plaques.Homeostatic chemokine CCL21 was up-regulated within the atherosclerotic lesions, which c
Background Paraoxonase l (PON1) is an high-density lipoprotein (HDL)-associated enzyme capable of inhibiting the progression of atherosclerosis, thus preventing the development of coronary artery dise