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The non-specific advanced glycation/oxidation of proteins and lipids have been long identified as a profound mechanism that results in irreversible physiological and biological deterioration of tissues and organs.The resulting advanced glycation and lipoxidation end products (AGEs &ALEs) have been implicated as the causative factors for the on set of various diseases including diabetes and its various complications.The concept of metabolic memory has been proven by numerous pre-clinical studies and large-scale clinical studies such as DCCT, UKPDS, ADVANCE and ACCORD.Several biomarkers along the mechanism of glycation and oxidation have demonstrated great clinical implication in achieving early diagnose and proper management of diabetes.The most recent publication by Dr.Denise Fraustman on Diabetes Care reveals that T1D patients have functional residual c-peptide lever up to 40 years being diagnosed.This new finding based on an ultra sensitive c-peptide assay has fundamentally changed the traditional believe that T1D patients wont have c-peptide left after one year being diagnosed.This latest discovery together with renewed view on C-peptides biological activities lead to a paradigm shift on finding cure for T1D.The time has come, more than ever, we need to change our mind setting and approach in the management of diabetes.