Aim Previous studies of limb-girdle muscular dystrophy type 2A (LGMD2A) in many countries have suggested a heterogeneous genetic and clinical spectrum.We aims to investigate the correlations between phenotypes and genotypes of Chinese patients with LGMD2A.Materials and Methods CAPN3 gene was directly screened in 18 Chinese Han subjects who exhibited severely reduced or completely absent calpain-3 expression, as determined by Western blot analysis.We subsequently analyzed genotype/phenotype correlations.