KLF4 recruits p300 to regulate p21 transcription via modulation of histone acetylation

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户:NSWDAR
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective: Gene activation in eukaryotes requires coordinated role of specific cell signals,transcription factor activation, chromatin modications, and chromatin remodeling.KLF4(Kruppel-like factor 4), which can be acetylated by p300, is closely involved in vascularsmooth muscle cell (VSMC) differentiation gene induced by transforming growth factor β1.
其他文献
Understanding of seed ageing, which leads to viability loss during storage, is vital for ex situ plant conservation and agriculture alike.Yet the potential for regulation at the transcriptional level
Clitocine is an amino nucleoside that has been shown to inhibit human cancer cell proliferation.Here, we reported that Clitocine effectively induced drug-resistant human cancer cells apoptosis in vitr
选取来自中国不同省份的野生大豆、栽培大豆地方品种和育成品种各41份,种植于网室,取苗期叶片按各品种等比例方式混合制成野生群体、地方群体、育成群体3个样品,TCA丙酮法提取蛋白质进行双向电泳.Melanie 7.0软件分析双向电泳图谱,在每张电泳图谱上平均找到727个蛋白点,按Ratio值>1.5筛选差异表达的蛋白点,对筛选到的差异点用SPSS11.0软件进行差异显著性分析,在3个群体间共获得表达有
ETHNOPHARMACOLOGICAL RELEVANCE: A medicinal herb Crotalaria Sessiliflora has been used to treat various diseases including diuretic, cardiotonic, analgesic, and anticancer in folk traditional medicine
黄花油点草(Tricyrtis maculata (D.Don) Machride.)为百合科油点草属的多年生草本.油点草属全世界约15种,广布于亚洲东部.我国产4种,产于华北和秦岭以南.在已有的植物有性生殖研究文献中,对百合科植物的生殖生物学研究报道较多,而有关油点草属植物生殖生物学研究很少.本论文通过对黄花油点草胚胎发育的研究,探讨其胚胎发育的特征,为百合科植物的系统发育研究提供生殖生物学方面
An ultrasonically assisted extraction (UAE) technique was applied to the extraction of flavonoid compounds from bamboo leaves, named N.affinis in present work.A factorial design employed to optimize e
甘遂(Euphorbia kansui Liou)隶属于大戟科(Euphorbiaceae)大戟属(Euphorbia),为多年生草本植物,主产于陕西、河南、山西、甘肃和宁夏等地.其主块根,苦寒有毒,具除水、利尿功效,主治各种水肿等,为我国传统中药,历代本草皆有收载.近年来,研究发现甘遂有效成分为二萜酯类,尤其是巨大戟萜醇型二萜酯类有显著的抗癌、抗病毒等活性.
Immotile spermatids produced in the testis must undergo a series of poorly understood morphological,physiological and biochemical processes called sperm activation to become motile,fertilization-compe
AMP-activated protein kinase (AMPK) is an evolutionarily conserved metabolic sensor crucial for the cellular energy homoeostasis.In response to reduced energy supply,AMPK switches off Adenosine-5-trip
会议
It is well-known that diabetes impairs male reproduction seriously.The objective was to investigatethe effects and mechanisms of advanced glycation end products(AGEs), whichplay important roles in dia