【摘 要】
：
In this work, we developed a method that allows precise control over changes in the size of a cell via hydrostatic pressure changes in the medium.Specifically,
【机 构】
：
DepartmentofMechanicalEngineering,TheUniversityofHongKong,HongKongDepartmentofEngineeringMechanics,Z
【出 处】
：
The 9th Asian Biophysics Association Symposium (ABA2015)(第九届
论文部分内容阅读
In this work, we developed a method that allows precise control over changes in the size of a cell via hydrostatic pressure changes in the medium.Specifically, we show that a sudden increase, or reduction, in the surrounding pressure, in the physiologically relevant range, triggers cross-membrane fluxes of sodium and potassium ions in leukemia cell lines K562 and HL60, resulting in reversible volumetric deformation with a characteristic time of around 30 minutes.Interestingly, healthy leukocytes do not respond to pressure shocks, suggesting that the cancer cells may have evolved the ability to adapt to pressure changes in their microenvironment.A model is also proposed to explain the observed cell deformation, which highlights how the apparent viscoelastic response of cells is governed by the microscopic cross-membrane transport.
其他文献
Teicoplanin (Tei) and lipo-congeners thereof serve as the last line antibiotics to treat serious infectious diseases caused by multidrug-resistant Gram-(+) path
Adenylyl cyclases (ACs) generate cAMP, a 2nd messenger of utmost importance that regulates a vast array of biological processes such as cell growth and differen
A series of studies aimed at developing methods and technologies of analyzing epigenetic information in cells and in those networks was examined to expand our u
Cardiomyocytes show hypertrophic growth and remodeling in response to prolonged mechanical stress or abnormal neurohumoral activation.Although the hypertrophic
Ionizing radiation can interact with DNA and induce numerous types of lesions within DNA.The studies on irradiated cells determined that effective triggering of
Pancreatic beta-cell plays a central role in the body blood homeostasis by systematically activating glucose uptake after food intake.Diabetes arises when beta-
Proteins are involved in almost all biological activities and their structures and functions are determined by their one-dimensional amino acids sequences.Since
Synaptic plasticity is key to the formation and reconfiguration of neuronal circuits.It is also an energy demanding process.Using a mitochondrion-targeting fluo
Transcription of DNA by RNA Polymerase Ⅱ (Pol Ⅱ), being the first step in producing proteins that are critical to the survival of the cell, represents a commo
Most cell types have the ability to sense and respond to the physiological fluid flow-derived shear stress.Dendritic cells (DCs) are currently the most powerful