论文部分内容阅读
研究背景：组蛋白修饰在免疫应答及重大疾病进展中功能的研究已逐渐成为免疫学研究的热点。前期，我们对14种已知参与H3K4甲基化修饰的酶进行siRNA介导的干扰普筛实验，发现Ashll在天然免疫应答和炎症发生发展中具有重大的调控作用。然而Ashll在适应性免疫应答中的调控作用仍亟待发现。
H3K4甲基化转移酶Ash11在诱导调节性T细胞(Treg)极化中的作用及机制研究
【摘 要】
：
研究背景：组蛋白修饰在免疫应答及重大疾病进展中功能的研究已逐渐成为免疫学研究的热点。前期，我们对14种已知参与H3K4甲基化修饰的酶进行siRNA介导的干扰普筛实验，发现Ash
【机 构】
：
中国医学科学院医学分子生物学及免疫学国家重点实验室
【出 处】
：
中国免疫学会第十届全国免疫学学术大会
【发表日期】
：
2015年期
其他文献
Reconstitution of T cell subsets and its clinical significance after related HLA-haploidentical peri
Introduction: To study the reconstitution and clinical significance of T cells subsets of patients undergoing related HLA-haploidentical non T-cell depleted
会议
Aim: Blockade of the protein-protein interaction between the transmembrane programmed cell death 1 protein (PD-1) and its ligand PD-L1 emerges as a promisin
会议
Atorvastatin-modified bone marrow-derived dendritic cells decrease Tfh and increase Breg in experime
Background: We previously demonstrated that atorvastatin induced immature dendritic cells (DCs) derived from spleen in vitro.
会议
Human gingival tissue-derived mesenchymal stem cells reduce the severity of murine acute-GVHD throug
Human gingival tissue-derived mesenchymal stem cells (GMSCs) are a convenient source of MSCs that have been shown to treat autoimmunc disease.
会议
目的：建立小鼠原位气管移植模型,研究Th17细胞对移植物的影响。方法：供受体按体质量配对后随机分为6组,同系移植组：C57BL/6→C57BL/6 (n=10)；同种移植组：BALB/c→C57BL/6 (n=1
会议
Foxp3+ Regulatory T (Treg) cells harbor immune suppressive capacities and are crucial for the maintenance of immune homeostasis and control of dominant immu
会议
Background:Chronic hepatitis B virus (HBV) infection is characterized by continuing liver inTo investigate the mechanisms which co-inhibitory pathway mediat
会议
Objective: To investigate the synergic role of TGF-β and IL-2 in regulating the balance between the regulatory T cells and conventional T cells, thus the h
会议
Background: Natural killer (NK) cell plays critical roles in anti-tumor immunity.T cell immunoglobulin and mucin domain-3 (Tim-3) is a well-known immune med
会议