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The Ras/Raf/MEK/ERK pathway(ERK pathway)is a member of the four distinct mitogen-activated protein kinase(MAPK)signaling pathways,which play critical roles in regulation of diverse cellular activities,and the members in this cascade are potential targets for antitumor agents.1 MEK is a critical node in ERK MAPK pathway,and it shows very high specificity for ERK.2 Now 12 MEK inhibitors are currently at some stage of clinical evaluation for the treatment of cancer.