2-deoxy-2-fluoroarabinonucleic acid(FANA),which is one type of xeno-nucleic acid(XNA),has been intensively studied in molecular medicine and synthetic biology because of its superior gene-silencing an
Though plenty of viral and non-viral methods have been rapidly developed for the delivery of the CRISPR/Cas9 system,the direct delivery of Cas9 ribonucleoproteins(RNPs)into the nucleus for genome edit
Based on the segmentation of influenza virus genome,it is possible for two distinct strains exchange intact genome segments when they co-infect one cell,termed reassortment.
CRISPR/Cas9 ribonucleoprotein(RNP)complexes are promising biological tools with diverse biomedical applications.However,to date there are no efficient methods that can produce these proteins at large