Demyelinating diseases include multiple sclerosis,which is a neurodegenerative disease characterized by oligodendrocyte immune attacks,resulting in myelin sheath damage and axonal loss in the central nervous system(CNS).Leucine-rich repeat and immunoglobulin domaincontaining neurite outgrowth inhibitory protein(Nogo)receptorinteracting protein-1(LINGO-1)has been identified as a negative regulator of oligodendrocytes.Targeted LINGO-1 inhibition promotes neuron survival,axon regeneration,oligodendrocyte differentiation,and remyelination in diverse animal models.Although studies in rodent models have extended our understanding of LINGO-1,its roles in neural development and myelination in zebrafish(Danio rerio)are not yet clear.