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PRELP is a glycosaminoglycan and collagen binding anchor protein highly expressed in cartilage,basement membranes,and developing bone,it plays an important role in osteoclastogenesis,however,the effect of PRELP on the differentiation of pre-osteoblastic cell line and the related mechanism has not been reported.Herein,we fist found that the expression of PRELP was up-regulated upon stimulation of mineralization in MC3T3-E1 cells.