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Objective: To analyze retrospectively the safety and efficacy of myeloablative conditioning regimen without anti-thymocyte globulin (ATG) and total body irradiation (TBI), but with fludarabine (FLU) in unrelated cord blood transplantation(UCBT) in 30 patients with hematologic malignancies.Methods: The myeloablative conditioning regimen consisted of FLU, busulfan (BU), and cyclophosphamide (CY).All patients received CSA and MMF as GVHD prophylaxis.