【摘 要】
：
Clofazimine (CLF),one of the Riminophenazine compounds,was first identified as riminophenazine inhibitors for Mycobacterium tuberculosis.Recently,we have discovered a series of CLF analogs with increa
【机 构】
：
Institute of Materia Medica,Peking Union Medical College &Chinese Academy of Medical Science,Beijing
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Clofazimine (CLF),one of the Riminophenazine compounds,was first identified as riminophenazine inhibitors for Mycobacterium tuberculosis.Recently,we have discovered a series of CLF analogs with increased MIC value which embrace improved solubility,PK and skin pigmentation properties.However,the mechanism of action of CLF has remained elusive.
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