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Recent advancements in micro-/nano-biomechanical instruments, such as micromanipulation and optical tweezers, have enhanced the mechanical characterisation of biological cells to a great extend.Micromanipulation enables the micro-force measurement of a single biological cell and tissue membrane at large deformations, while optical tweezers allows to the cell force measurement as low as 100 pN.These measurements can also be incorporated with cellular mechanical modelling to facilitate the determination of the mechanical properties, such as the elasticity and rupture strength of single cells.