【摘 要】
：
An essential step in intricate visual processing is the segregation of visual signals into ON and OFF pathways by retinal bipolar interncurons.We found that TRPM 1-L is a component of the ON BC transd
【机 构】
：
Osaka Bioscience Institute;PRESTO, JST, Japan
【出 处】
：
中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
An essential step in intricate visual processing is the segregation of visual signals into ON and OFF pathways by retinal bipolar interncurons.We found that TRPM 1-L is a component of the ON BC transduction channel.We identified a mouse trpml homologue of human TRPM1.Trpml is alternatively spliced, resulting in the production of a long form (trpml-L) and a short N-terminal form (trpml-S).Although mouse trpml-S was previously identified as melastatin, mouse trpml-L was not identified.Without distinction between trpml-L or-S, trpml has been reported to be detected in human primary melanocytes, poorly metastatic melanoma cell lines, mouse retinal pigment epithelium (RPE), and subsets of ON and OFF BCs.We found that TRPM1-L localization is developmentally restricted to the dendritic tips of ON BCs in co-localization with mouse GRM6 (mGluR6).
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