Non-small Cell Lung Cancer Presenting with Choroidal Metastasis as First Sign and Showing Good Respo

来源 :BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会) | 被引量 : 0次 | 上传用户:lxj13050621544
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  Metastatic tumors are the most common intra-ocular malignancies and choroid is by far the most common site for intra-ocular malignancies.Multiple foci are usually involved, and bilateral involvement is frequently seen.The primary sites for choroidal metastasis in decreasing order and by gender are: breast, lung, unknown primary, gastrointestinal and pancreas, skin melanoma and other rare sources in females, and lung, unknown primary, gastrointestinal and pancreas, prostate, kidney, skin melanoma and other rare sources in males.Available treatment options are external beam radiotherapy and plaque radiotherapy, while new methods like surgical resection, trans-pupillary thermotherapy and intra-vitreal chemotherapy offer promises for the future.The use of chemotherapy alone for choroidal metastases is not widely reported.We present case of a 50-year-old Indian man who had a unilateral solitary lesion in his right eye.He was found to have an adenocarcinoma of the lung with choroidal metastasis as the first presenting sign.There were no findings of metastasis involving his contralateral eye.He was administered chemotherapy based on gemcitabine and carboplatin.He had significant progressive subjective and objective improvement since his first chemotherapy.His current best corrected visual acuity is 20/30 after six cycles of chemotherapy.Chemotherapy alone can be considered an effective mode of treatment in patients in whom primary tumors show good response to chemotherapy.
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