【摘 要】
：
Radiotherapy is an important lung cancer treatment modality.However,its efficacy is often compromised by the radioresistance of cancer cells and radiation-induced toxicity to normal lung tissue.TGF-β1
【机 构】
：
School of Radiation Medicine and Protection,Medical College of Soochow University/School for Radiolo
论文部分内容阅读
Radiotherapy is an important lung cancer treatment modality.However,its efficacy is often compromised by the radioresistance of cancer cells and radiation-induced toxicity to normal lung tissue.TGF-β1 has been reported to be involved in lung injury and fibrosis after radiotherapy.Thus targeting TGF-β1 might prevent radiation-induced normal tissue toxicity.On the other hand,TGF-β1 inhibition has been found to increase radiosensitivity of breast cancer cells.
其他文献
In cancer radiotherapy,apoptosis is a well-recognized cell death mechanism through which cytotoxic agents kill tumor cells.Caspase 3 is generally recognized as a key downstream effector execution phas
目的:观察不同肿瘤细胞在放化疗抵抗中的作用及机制,探讨翻译调控肿瘤蛋白(Translationally controlled tumor protein,TCTP)和转化生长因子-β(transforming growth factor-beta,TGF-β)在此过程中发挥的作用.方法:实验选用人肠癌细胞SW480 和SW620、人肺癌细胞A549 和PC14、人乳腺癌细胞MCF-7 和MDA-M
目的:p21 被报道参与了辐射诱导的旁效应过程,同时研究发现抑制p21 基因对于hus1基因缺失的小鼠胚胎成纤维细胞(MEFs)的体外连续培养是必需的,提示p21 基因与hus1基因相互关系密切.本实验主要是研究p21 和hus1 在低剂量α 粒子辐照的MEFs 中介导旁效应的过程.
Endothelial colony-forming cells (ECFCs) are endothelial progenitor cells that circulate at low concentration in human umbilical cord and adult peripheral blood and are largely resident in blood vesse
近年来,Toll类受体(Toll-like receptors,TLRs)及其激动剂在抗辐射损伤中的防治作用正引起放射生物学界的高度重视,2008年,受到美国国防部和NIH (national institutes of health)资助的Cleveland生物实验室在Science 杂志上报道其研究的改良型TLR5激动剂CBLB502(一种沙门氏菌毛蛋白)具有极强的辐射损伤防护效应,结果显示即
The Nobel Prize 2011 went to Jules Hoffman and Bruce Beutler for their discoveries of Toll-like receptors (TLRs),while Albert Lasker Award for Basic Medical Research 2008 honored the discovery of micr
The heavy ion medical accelerator in Chiba (HIMAC) is the worlds leading heavy ion cancer treatment facility,and more than 8000 of patients with various radioresistant cancers were treated by HIMAC,an
Passive beam delivery system including lateral beam shaping,range adjustment and modulation,and lateral field tailoring has been developed at the Institute of Modern Physics(IMP),Chinese Academy of Sc
It has been known that genome instability exists in many cancers,and it may be a potential cause of tumorigenesis.Our studies demonstrated that genomic instability can be induced by ionizing radiation
Intense neutron generator based on D-D/D-T reaction plays an important role inthe following potential research fields,such as materials-damage studies,crosssection data measurement of key nuclides,tri