【摘 要】
：
Porcine reproductive and respiratory syndrome virus (PRRSV) infection appears to elicit a week innate immune response.Several nonstructural proteins (NSPs) encoded by PRRSV genome antagonize type I in
【机 构】
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State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Ac
【出 处】
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2013国际猪繁殖与呼吸综合征学术研讨会
论文部分内容阅读
Porcine reproductive and respiratory syndrome virus (PRRSV) infection appears to elicit a week innate immune response.Several nonstructural proteins (NSPs) encoded by PRRSV genome antagonize type I interferon (IFN) system in PRRSV-infected PAMs.However,the nonstructural proteins-interacting partners and their influence on the outcome of antivirus infection are poorly defined.In this study,yeast two-hybrid was used to screen PAM cDNA library to identify the binding protein(s) of nonstructural proteins encoded by PRRSV genome.Swine immunoglobulin lambda-like peptide 5 (sIGLL5),was identified as a novel interacting partner of NSP4 and NSP11.
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