Median lethal death,LD50,is a general indicator of compound acute oral toxicity(AOT).Various in silico methods were developed for AOT prediction to reduce costs and time.
Machine learning methods for constructing quantitative structure-activity relationship(QSAR)or quantitative structure-property relationship(QSPR)models were widely applied in drug discovery,environmen
The emergence and spread of antibiotic resistance represent a severe global issue.New drug targets and novel lead compounds that exempt from cross-resistance to existing drugs are urgently needed.
Elevated expression of polo-like kinase 1(Plk1)has been reported in a wide spectrum of cancers in humans,and inhibition of Plk1 activity results in mitotic arrest and apoptosis [1-5].
Near infrared(NIR)spectroscopy combined with multivariate calibration has been widely used for the quantitative analysis of complex samples in petrochemical,agricultural,pharmaceutical and other field
In this work,a ratiometric fluorescent aptamer sensor was developed to achieve the simple,rapid and label-free detection of Pb2+based on the quantitative fluorescence model(QFM)and dual wavelength mon