论文部分内容阅读
Objective The integration of imaging and therapeutic capability into a single platform has shown great potentials in drug delivery,image-guided minimally invasive therapy,and so on.However,how to achieve the synergistic therapy with synchronous imaging diagnosis and treatment monitoring for tumor by using single-component carrier is still in a great challenge.Materials All chemicals were of analytical grade and used directly without further purification.Polyvinylpyrrolidone (PVP, K30), potassium ferricyanide (K3 [Fe (CN)6]), hydrochloric acid (HCl,36.0% ~ 38.0%) and perfluoropentane (PFP, Sigma-Aldrich-Co.LLC.) were purchased from Sinopharm chemical Reagent Co., Ltd.Methods Firstly,PVP (3.0 g),K3[Fe(CN)6] (132 mg) and HCl solution (0.01 M,40 ml) were mixed under magnetic stirring.After obtaining a clear solution, the vial was put into an eletric oven at 80 ℃ for 24 h.Then, through centrifuged and washed in distilled water several times, mesoporous Prussian blue nanoparticles (MPBs) were obtained.Hollow mesoporous Prussian blue nanoparticles (HMPBs) were successfully prepared using polyvinylpyrrolidone (PVP) as a protectant, and hydrochloric acid as a etchant.