Pyridines are ubiquitous in many bioactive natural products,organic conducting materials,and pharmaceutical compounds.1 Although there are many synthetic methods for the construction of pyridines,most of them suffer from several drawbacks.Further development of efficient and practical procedures that maximize step economy with easily accessible starting materials to construct these valuable skeletons remains highly desirable.Herein,we describe a palladium-catalyzed Heck-type reaction of oximes and allylic alcohols to afford different substituted pyridines with efficient chemoselectivity.The mild reaction conditions,simple reaction system and readily functionalized products make the present protocol very attractive,which can be directly used to functionalized material synthesis.