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  5. Pan-cancer analysis based on transcriptional response reveals similarity among different human cance

Pan-cancer analysis based on transcriptional response reveals similarity among different human cance

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：tang790330
【摘 要】
：
Background: Cancer is the leading cause of death all over the world.The molecular mechanisms of cancer occurrence, development and metastasis are quite complicated.A lot of studies have been done for
【作 者】
：
胡朔枫 邵宁生 郑晓飞 伯晓晨 应晓敏 韩露 陆启轩 鲁亮群 李宗城 陈垚文 沈孝陵 张健 张筱凤 
【机 构】
：
基础医学研究所,军事医学科学院,北京,100850 放射与辐射医学研究所,军事医学科学院,北京,1
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
Cancer-cancer network transcriptional responses gene expression signature 
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　　Background: Cancer is the leading cause of death all over the world.The molecular mechanisms of cancer occurrence, development and metastasis are quite complicated.A lot of studies have been done for different cancer classes separately.However pan-cancer analysis on molecular aberrations at DNA level reveals that similar mechanism might underlie different cancers.Transcriptional responses of tumors reflect the transcriptional variation in disease state compared to the normal tissues.Analysis on transcriptional responses across many different tumor types could provide new insight into cancers.So in this study, we present an exploration based on transcriptional responses to discover the similarity, instead of the difference, among cancers.
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