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  5. Effect of Oxymatrine on TGF-β/Smad Signaling Pathway in Human Keloid Fibroblasts

Effect of Oxymatrine on TGF-β/Smad Signaling Pathway in Human Keloid Fibroblasts

来源 :第三届全球华裔整形外科医师大会 | 被引量 : 0次 | 上传用户：wangxiaomax
【摘 要】
：
Objective To study the mechanism of the suppression of oxymatrine on collagen synthesis of human keloid fibroblasts.Metholds Human keloid fibroblasts were cultu
【作 者】
：
FanDongliang[1]GuoShu[1]LiuJinchao[2]WangYuxin[1] 
【机 构】
：
Department of plastic surgery, First affiliated hospital of China medical university,Shenyang 110001
【出 处】
：
第三届全球华裔整形外科医师大会
【发表日期】
：
2012年期
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Objective To study the mechanism of the suppression of oxymatrine on collagen synthesis of human keloid fibroblasts.Metholds Human keloid fibroblasts were cultured as an experimental model.The effect of oxymatrine on TGF-β/Smad signaling pathway were analyzed by Western Blot.Meanwhile,the mRNA of positive molecule were analyzed by RT-PCR.ResultsThe expression of TGF-β1,TβRI,TβRII,Smad4,Smad7 were insignificant compared to control group.
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