Effect of Oxymatrine on TGF-β/Smad Signaling Pathway in Human Keloid Fibroblasts

来源 :第三届全球华裔整形外科医师大会 | 被引量 : 0次 | 上传用户:wangxiaomax
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective To study the mechanism of the suppression of oxymatrine on collagen synthesis of human keloid fibroblasts.Metholds Human keloid fibroblasts were cultured as an experimental model.The effect of oxymatrine on TGF-β/Smad signaling pathway were analyzed by Western Blot.Meanwhile,the mRNA of positive molecule were analyzed by RT-PCR.ResultsThe expression of TGF-β1,TβRI,TβRII,Smad4,Smad7 were insignificant compared to control group.
其他文献
Objective:To explore the clinical application of modified circumcision with penile augmentation for capistration or redundant prepuce.Methods:Excising skin only
会议
Objective In order to improve the aesthetic results of restoration of bony deformities in maxillofacial region.To introduce the technique about restoration of b
会议
今年来,科普类视觉设计在市场长的需求日益增加.本文将从传播心理学的视角出发,通过分析公众的心理和认知特点,对公众科普信息传播视觉设计的设计思路提出合理化建议.
OBJECTIVE:During the early process of ear reconstruction in cases of microtia patients,we used the remnant to repair some structures of the ear in the first sta
会议
李碧华,香港文坛大名鼎鼎的才女。她才高八斗,行踪神秘,从不在大庭广众前抛头露面,坚持出书不公开照片、不安排签名售书,为此主动放弃了香港畅销书作家排行榜,被誉为港岛最神秘的女作家。在30多年的写作生活里,有百部作品问世,其中《胭脂扣》《霸王别姬》《纠缠》《秦俑》《诱僧》《青蛇》等被改编成影视剧,不仅捧红了张国荣、梅艳芳等明星,还摘取过戛纳大奖。    专栏比拼,结识博学夫君    李碧华出生于广东省
Background:This study was undertaken to improved surgical management of bilateral complete deft lip.To realizete the need of preoperative manipulation of the pr
会议
加强客户营销是优化我行信贷资金配置的迫切需要。当前棉花收购主体多元化,市场竞争异常激烈,对棉花收购资金需求非常旺盛,迫切需要我们在市场调查的基础上,对客户进行细分,
Objective To study the gene expression of transforming growth factor β1 (TGF-β1)and β-catenin and to explore their effect in pathological scars.Methods RT-PC
会议
Objective To investigate the expression of GSK3β of Wnt/β-catenin pathway in pathological scar and make sure that the role of GSK3βin the pathogenesis of pat
会议
Objective To study the effects of oxymatrine on collagen synthesis of human keloid fibroblasts.Methods Human keloid fibroblasts were cultured as an experimental
会议