【摘 要】
：
To expand our understanding on how the ribosome functions in the various steps of protein synthesis, we have determined the structures of the 70S ribosome b
【出 处】
：
The 3rd Canton Nucleic Acids Forum(第三届广州核酸国际论坛)
论文部分内容阅读
To expand our understanding on how the ribosome functions in the various steps of protein synthesis, we have determined the structures of the 70S ribosome bound to several protein factors captured in different steps of the process.Our structure of the 70S ribosome bound to elongation factor G (EF-G) captured in a compact state of EF-G and three tRNA molecules provides insights into how EF-G promotes translocation.Our structures of many complexes of the 50S and 70S ribosomes with antibiotics show how they inhibit protein synthesis, how mutations make them resistant to antibiotics and how new antibiotics can be developed.Recently, we have shown how an oligopeptide binds in the ribosome peptide tunnel and can inhibit protein synthesis.
其他文献
内容提纲阿尔兹海默病(AD)的全球危机老年期常见疾病与AD关系密切如何识别老年患者中的AD?老龄化进程日益加速痴呆全球机□2010年,全球痴呆患者达3560万,其中919万在中国,为
Traditional measures · Survival (overall or disease-specific)· Biomarkers · Disease-specific signs and symptoms · Disease-specific function or HRQOL Patient
65岁以上人群冠心病死亡率显著上升男性及女性冠心病死亡率均随年龄更加而增加,尤其在老年人群中致死率显著升高.成年人胆固醇水平随年龄增高趋势TC水平对各年龄段心血管疾病
概述·肺栓塞(pulmonary embolism,PE)是一致死性心肺疾病·肺栓塞是内源性或外源性栓子阻塞肺动脉引起肺循环障碍的临床和病理生理综合征,包括肺血栓栓塞症、脂肪栓塞综合征
从转化医学到精准吸血的提出"精准医学"历史沿革1000多年前中国传统医学提出"辩证施治","同病异治、异病同治"因此,精准医学是医学自身发展的客观必然,是公众对健康需求的推
I will summarize our current efforts to understand more about circular RNAs (circRNAs).Recently, circRNAs (single-stranded covalently closed RNAs) have been
Addgene (www.addgene.org) is a nonprofit organization that accelerates biomedical research and discovery by improving access to useful research materials an
Recent studies came up with novel RNAi triggering molecular structures with unique structural features and functional advantages compared with the conventio
Sample prep plays critical role in modern molecular testing, which is striving for high content and high specificity, to ensure high and unbiased recovery.W