【摘 要】
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To expand our understanding on how the ribosome functions in the various steps of protein synthesis, we have determined the structures of the 70S ribosome b
【出 处】
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The 3rd Canton Nucleic Acids Forum(第三届广州核酸国际论坛)
论文部分内容阅读
To expand our understanding on how the ribosome functions in the various steps of protein synthesis, we have determined the structures of the 70S ribosome bound to several protein factors captured in different steps of the process.Our structure of the 70S ribosome bound to elongation factor G (EF-G) captured in a compact state of EF-G and three tRNA molecules provides insights into how EF-G promotes translocation.Our structures of many complexes of the 50S and 70S ribosomes with antibiotics show how they inhibit protein synthesis, how mutations make them resistant to antibiotics and how new antibiotics can be developed.Recently, we have shown how an oligopeptide binds in the ribosome peptide tunnel and can inhibit protein synthesis.
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