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The present study aims to examine the effects of Mullberry Leaves on plasma lipid in hypedipidemic mice.The beverage of Mullberry leaves was obtained after being extracted and concentrated.The hyperlipidemic mice were induced by lipid-rich diet for 5 weeks.Whereas the above beverage was simultaneity administered,it exhibited strong activity in reducing plasma cholesterol,triglyceride and low-density lipoprotein-cholesterol concentrations and increasing the ratios of high-density lipoprotein-cholesterol to triglyceride in mice.The results showed that this beverage of mulberry leaves was effective in restraining plasma lipid concentrations in lipid-rich diet mice.